What would the world be like if the human body was totally immune or impervious to all possible drugs that could be used recreational? For example, humans could drink alcohol, but it would only make us sick, not affect our brain, relax us, or cause us to lose good judgment. Tranquilizers, Heroin, Cocaine, Meth, & Marijuana did nothing to provide a pleasurable feeling. Yeah we'd probably need some drug that would stop pain for injuries or surgery --but it wouldn't cause any pleasurable effect that could make it desirable for recreation.
What would the world be like in that situation?
Free trade would prevail -- it seems that one of the main reasons for preventing free trade is to tax alcohol and tobacco.
Prisons would be very empty or non-existent, since many crimes are committed while under the influence, and a large percentage of our prisoners are there due to either using, making or selling drugs -- or laundering money made from drugs.
Religions would probably be more popular. It is well known that religious experiences due to music, chanting etc have pleasurable effects similar to drugs.
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